Versatile and Scalable Method for Producing N-Functionalized Imidazoles was written by Bara, Jason E.. And the article was included in Industrial & Engineering Chemistry Research in 2011.Reference of 21252-69-7 This article mentions the following:
A method for producing sodium imidazolate (NaIm) at a scale of ∼400 g from only commodity starting materials has been developed. The NaIm product was then utilized as a starting material to produce 20 different N-functionalized imidazole and bis(imidazole) compounds, with the application of a common procedure involving minimal solvent volumes and straightforward purification via flash chromatog. and solvent evaporation Generating N-functionalized imidazoles “on demand” from NaIm and alkyl halides (or similar compounds) can eliminate the need for hazardous starting materials such as NaH and anhydrous solvents that have typically been employed in their synthesis. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).
1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 21252-69-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem