Related Products of 33468-69-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.
4-Bromo-6-cyclohexyl-pyrane-2-one (257mg, L. OOMMOL) and 4-trifluoromethyl- 1H-imidazole (204mg, 1. 50MMOL) were dissolved in acetonitrile (50ML) in a 100mL flask, and K2CO3 (414mg, 3. 00MMOL) and KI (25mg, 10% w/w) were added thereto. The reaction solution was heated under reflux. After 15 hours, the reaction solution was cooled down to room temperature and then filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel using MC: MEOH (20: 1) as eluent. The fractions containing the product were combined and evaporated to give a white solid (298mg, 96%). ‘H-NMR (CDC13) ; 8 = 7.99 (s, 1H), 7.64 (s, 1H), 6.17 (dd, 2H), 2.53 (m, 1H), 2.1- 1.2 (m, LOH).
The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-imidazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; C & C RESEARCH LABORATORIES; WO2004/50624; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem