Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells was written by Guetzoyan, Lucie J.;Spooner, Robert A.;Boal, Frederic;Stephens, David J.;Lord, J. Michael;Roberts, Lynne M.;Clarkson, Guy J.. And the article was included in Molecular BioSystems in 2010.Product Details of 58442-17-4 This article mentions the following:
The small mol. 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphol. changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those induced by brefeldin A. Both brefeldin A and Exo2 protect cells from intoxication by Shiga(-like) toxins by acting on other targets that operate at the early endosome, but do so at the cost of high toxicity to target cells. The advantage of Exo2 is that it is much more amenable to chem. modification and here we report a range of Exo2 analogs produced by modifying the tetrahydrobenzothienopyrimidine core, the vanillin moiety and the hydrazone bond that links these two. These compounds were examined for the morphol. changes they stimulated at the Golgi stack, the trans-Golgi network and the transferrin receptor-pos. early endosomes and this activity correlated with their inherent toxicity towards the protein manufacturing ability of the cell and their protective effect against toxin challenge. We have developed derivatives that can sep. organelle morphol., target specificity, innate toxicity and toxin protection. Our results provide unique compounds with low toxicity and enhanced specificity to unpick the complexity of membrane trafficking networks. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Product Details of 58442-17-4).
1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 58442-17-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem