Formylation of 1-methylbenzimidazoles was written by Tertov, B. A.;Koblik, A. V.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1967.SDS of cas: 3012-80-4 This article mentions the following:
To 0.8 g. Na (activated with iso-amyl alc.) in 2.5 ml. HCONMe2 and 45 ml. C6H6, 4 g. 1-methylbenzimidazole was added and the whole stirred under N 1.5 hrs., 5 ml. AcOH in 20 ml. H2O added in one portion, and the mixture worked up to give 0.7 g. 1-methyl 2-formylbenzimidazole (I) m. 109-10°; oxime m. 215-16°. To obtain the Cu salt of 1-methylbenzimidazole-2-carboxylic acid a 5% solution of CuSO4 was added to the reaction mixture to which 80% EtOH was added instead of AcOH to destroy excess Na. From this, the free 1-methylbenzimidazole-2-carboxylic acid (II), m. 90-1°, was obtained. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4SDS of cas: 3012-80-4).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. SDS of cas: 3012-80-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem