Cobalt(
A series of chiral (imidazoline-oxazoline) N,N-bidentate ligands derived from 2,2-dimethylmalonic acid were conveniently synthesized and characterized. With the aid of the new ligands, the first Co(II)-catalyzed asym. Michael addition of 2-acetyl azaarenes to β-CF3-β-disubstituted nitroalkenes was successfully achieved, producing chiral compounds with a trifluoromethylated all-carbon quaternary stereocenter in good yields with enantioselectivities of up to 98% ee. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C6H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem