Adding a certain compound to certain chemical reactions, such as: 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33468-69-8, Safety of 4-(Trifluoromethyl)-1H-imidazole
Reaction Scheme 14 [00180] Referring to Reaction Scheme 14, Stage 1, a solution of 4-chloro-6-(3,4- dichloro-phenyl)-pyrimidine (leq), 4-(trifluoromethyl)-lH-imidazole (2eq) and potassium carbonate (l . leq) in fert-butanol (lOvol) was heated at 150C in a microwave for 25 minutes. Potassium carbonate (l .leq) was added to the reaction mixture, which was heated at 160C in a microwave for 35 minutes. Water was added and the desired material was extracted with EtOAc. The organic phase was dried with MgS04, filtered and evaporated to dryness. Purification by flash column chromatography (eluent: [99.5:0.5] DCM:MeOH) afforded the target compound.
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Reference:
Patent; CHDI, INC.; DOMINGUEZ, Celia; TOLEDO-SHERMAN, Leticia, M.; WINKLER, Dirk; BROOKFIELD, Frederick; DE AGUIAR PENA, Paula, C.; WO2011/91153; (2011); A1;,
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