144689-93-0, Adding a certain compound to certain chemical reactions, such as: 144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144689-93-0.
A mixture of ethyl-4-(1 -hydroxy-1 -methylethyl)-2-propylimidazole-5- carboxylate (5.0 g), potassium carbonate (5.75 g), and toluene (50 mL) is stirred at 45-500C for 45 minutes. N-(triphenylmethyl)-5-[4′-(bromomethyl)biphenyl-2- yl]tetrazole (13.2 g) and tetrabutylammonium bromide (1.3 g) are added and the mixture is stirred at 60-70 0C for 10 hours. The insoluble material is removed by filtration and the filtrate is washed with water (2*50 mL) at 60-700C. The filtrate is distilled under vacuum to produce a syrup. Methanol (25 mL) is added to the residue and stirred for 15 minutes at 25-35C. The mass is cooled to 0-5 0C and stirred at that temperature for 45 minutes. The precipitated solid is collected by filtration, washed with methanol (10 mL), and dried at 50-600C for 6 hours (yield 13.3 g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; KOLLA, Naveen Kumar; MANNE, Nagaraju; NAREDLA, Anitha; SHINDE, Sachin Gulabrao; WO2011/14611; (2011); A2;,
Imidazole – Wikipedia,
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