In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5955-72-6, name is 2-Chloro-6-nitro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H4ClN3O2
PROCEDURE: 2-chloro-5-nitro-1H-benzo[d]imidazole (200 mg, 1.012 mmol) is slurried with ethanol (6 mL), water (2 mL), and dimethylformamide (0.5 mL). Iron (283 mg, 5.06 mmol), and ammoniumchloride (271 mg, 5.06 mmol) were added and the reaction mixture was heated to reflux for 30 mm. The crude mixture was filtered and the resulting filtrate was concentrated and compound was purified by flash column chromatography (2% CH3OH/CH2C12) afforded the title compound 2-chloro-1H-benzo[d]imidazol-5-amine (150 mg, 0.877 mmol, 87 % yield) as a solid. Proton nuclear magnetic resonance (?1HNMR?) (400 MHz, DMSO-d6): oe 7.14 (d, 1H, J = 8.4 Hz), 6.56 (s, 1H), 6.49 (d, 1H, J = 8.8 Hz), 4.92 (bs, 2H).
The synthetic route of 5955-72-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY OF UTAH; VANKAYALAPATI, Hairprasad; SHARMA, Sunil; SORNA, Venkataswamy; WO2015/31564; (2015); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem