Lin, Shu-yu published the artcileStudy on compatible stability of esomeprazole sodium for injection with six kinds of common solvents, Computed Properties of 161796-78-7, the publication is Yiyao Daobao (2012), 31(9), 1210-1213, database is CAplus.
The appropriate HPLC detection for studying the stability of esomeprazole (Eso) sodium for injection with six kinds of common solvents was investigated, and thus provided an evidence for using reasonable compound preparation in clin. use. The Eso sodium for injection was compatible with 100 mL six kinds of common solvents resp., and the pH value was detected. The content of Eso sodium in the compatible solution was analyzed by HPLC. The color and clarity were observed at regular time. Eso showed a good linear relationship within the range of 0.05-1.60 mg·mL-1 (R2=0.9999). There were no significant changes on pH value, color, clarity and content within 24 h after being mixed with 0.9% sodium chloride injection and xylitol one. No distinct changes appeared 12 h, 8 h and 6 h after being mixed with 10% GS, 5% GS, 5% GNS injection, and the Eso solutions of which were relatively stable. While, the situation was different for Eso mixed with fructose injection. Eso was incompatible with fructose injection and showed better compatibility with 0.9% NS or 5% xylitol injection. The drip of admixture should be finished within 12 h, 8 h and 6 h when mixing with 10% GS, 5% GS, 5% GNS, resp.
Yiyao Daobao published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Computed Properties of 161796-78-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem