Yu, Hua-Zhong published the artcileReading Disc-Based Bioassays with Standard Computer Drives, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Accounts of Chemical Research (2013), 46(2), 258-268, database is CAplus and MEDLINE.
Traditional methods of disease diagnosis are both time-consuming and labor-intensive, and many tests require expensive instrumentation and trained professionals, which restricts their use to biomedical laboratories Because patients can wait several days (even weeks) for the results, the consequences of delayed treatment could be disastrous. Therefore, affordable and simple point-of-care (POC) biosensor devices could fill a diagnostic niche in the clinic or even at home, as personal glucose meters do for diabetics. These devices would allow patients to check their own health conditions and enable physicians to make prompt treatment decisions, which could improve the chances for rapid recovery and cure. Compact disks (CDs) provide inexpensive substrate materials for the preparation of microarray biochips, and conventional computer drives/disk players can be adapted as precise optical reading devices for signal processing. Researchers can employ the polycarbonate (PC) base of a CD as an alternative substrate to glass slides or silicon wafers for the preparation of microanal. devices. Using the characteristic optical phenomena occurring on the metal layer of a CD, researchers can develop biosensors based on advanced spectroscopic readout (interferometry or surface plasmon resonance). If researchers integrate microfluidic functions with CD mechanics, they can control fluid transfer through the spinning motion of the disk, leading to “lab-on-a-CD” devices. Over the last decade, the authors’ laboratory has focused on the construction of POC biosensor devices from off-the-shelf CDs or DVDs and standard computer drives. Besides the initial studies of the suitability of CDs for surface and materials chem. research (fabrication of self-assembled monolayers and oxide nanostructures), an ordinary optical drive, without modification of either the hardware or the software driver, can function as the signal transducing element for reading disk-based bioassays quant. In this Account, the authors first provide a brief introduction to CD-related materials chem. and microfluidics research. Then the authors describe the mild chem. developed in the authors’ laboratory for the preparation of computer-readable biomol. screening assays: photochem. activation of the polycarbonate (PC) disk surface and immobilization and delivery of probe and target biomols. The authors thoroughly discuss the anal. of the mol. recognition events: researchers can “read” these devices quant. with an unmodified optical drive of any personal computer. Finally, and critically, the authors illustrate the authors’ digitized mol. diagnosis approach with three trial systems: DNA hybridization, antibody-antigen binding, and ultrasensitive lead detection with a DNAzyme assay. These examples demonstrate the broad potential of this new anal./diagnostic tool for medical screening, on-site food/water safety testing, and remote environmental monitoring.
Accounts of Chemical Research published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C7H16ClNO2, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem