Reference of 5465-29-2, The chemical industry reduces the impact on the environment during synthesis 5465-29-2, name is 2-Propylbenzimidazole, I believe this compound will play a more active role in future production and life.
2-Propyl-1H-benzo[d]imidazole (Synthetic Communication, 2002, vol. 32, p3703, 246 mg, 1.54 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (550 mg, 1.54 mmol) obtained in Reference Example 1 were dissolved in DMF (7 mL), potassium carbonate (1.06 g, 7.68 mmol) was added and the mixture was stirred overnight. To the mixture was added water (20 mL), and the precipitated crystals were collected by suction filtration to give the title compound (640 mg, 94%). ESIMS m/z: 438 (M + H)+; 1H NMR (300 MHz, CDCl3,delta): 1.02 (t, J = 7.4 Hz, 3H), 1.77-1.97 (m, 2H), 2.23 (s, 3H), 2.80 (t, J = 7.4 Hz, 2H), 4.73 (d, J = 12.6 Hz, 1H), 5.32-5.48 (m, 3H), 6.51-6.58 (m, 1H), 6.59-6.69 (m, 1H), 6.94-7.07 (m, 3H), 7.11-7.29 (m, 3H), 7.43 (d, J = 7.8 Hz, 1H), 7.78 (d, J = 7.5 Hz, 1H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Propylbenzimidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; YAMAMOTO, Keisuke; TAMURA, Tomohiro; NAKAMURA, Rina; UENO, Kimihisa; HOSOE, Shintaro; EP2740730; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem