Ismaiel, Saad A. published the artcileVolumetric determination of antazoline, diphenhydramine, and ephedrine in some pharmaceutical preparations, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmazie (1975), 30(1), 58, database is CAplus and MEDLINE.
Antazoline-HCl (I) [2508-72-7] or diphenhydramine-HCl (II) [147-24-0] can be determined in the presence of ephedrine-HCl (III) [50-98-6] by a modification of the nonaqueous titrimetric method of BP 1973, i.e., by the prior addition of pure NaHCO3 and cooling to <15° (to prevent decomposition of NaHCO3 → Na2CO3), extraction of the liberated I and(or) II with CHCl3, the addition of NaOH to the separated aqueous layer and extraction of the liberated III with CHCl3. The CHCl3 solutions were evaporated and the residues titrated with HClO4 (crystal violet, indicator). The method compares favorably with that of Ismaiel (ibid. 1974).
Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem