Wang, Yue-mei published the artcileNew synthesis of fungicide cyazofamid, Synthetic Route of 120118-14-1, the publication is Nongyao (2015), 54(5), 324-326, database is CAplus.
Aims: This paper aims to report the new synthesis of fungicide cyazofamid. Methods: The compound was synthesized using 4-acetyltoluene as raw materials, through reactions of the oxidation, esterification, ammoniation, dehydration, chlorination and sulfonylation to obtain cyazofamid. And the paper mainly discussed the optimum process conditions for synthesizing substituted imidazole ring: reaction temperature is 85°C, reaction time is 10 h, ethanol as the solvent and n[2-oxo-2-(p-tolyl)acetaldehyde]:n[(NH4)2CO4]:n[glyoxylic acid (50% water solution) ]:n(triethylamine) = 1:1.5:3:5. Results: The total yield was 37.0%. Conclusions: The process is simple, the reaction conditions are mild, all the intermediates are easy to be purified and identified.
Nongyao published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C8H6ClN, Synthetic Route of 120118-14-1.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem