Yu, Min published the artcileHPLC peak positioning of omeprazole sulphone and esomeprazole sodium, Formula: C17H18N3NaO3S, the publication is Zhongguo Kangshengsu Zazhi (2012), 37(10), 773-775, 788, database is CAplus.
The eluotropic series of the main component esomeprazole sodium and its impurity omeprazole sulfone in different HPLC conditions were determined The HPLC methods adopted Welch Materials Xtimate-C8 column (4.6mm×250mm, 5 μm), Phenomenex b-sil- C8 column (4.6mm×250mm, 5 μm), Zorbax Eclipse XDB-C8 column (4.6mm×250mm, 5 μm), Kromasil-C8 column (4.6mm×150mm, 5 μm), Spherisorb-C8 column (4.6mm×150 mm, 5 μm), Welch Materials Welchrom-C8 column (4.6mm×250mm, 5 μm), 0.01 mol/L disodium hydrogen phosphate solution (adjust pH to 7.6 with phosphoric acid)-acetonitrile (67:33) as mobile phase, the flow rate was 1.0 mL per min. The detection wavelength was 280 nm. And the injection volume was 20 μL. The eluotropic series of esomeprazole sodium and omeprazole sulfone in HPLC were influenced by the column, not by the other conditions. The main influencing factor for the eluotropic series of esomeprazole sodium and omeprazole sulfone in HPLC was column.
Zhongguo Kangshengsu Zazhi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C3H5F3O, Formula: C17H18N3NaO3S.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem