Qin, Xu-feng published the artcileDetection and control of impurities in esomeprazole sodium for injection, Synthetic Route of 161796-78-7, the publication is Shandong Huagong (2014), 43(3), 21-25, database is CAplus.
Objective: To establish a method to determine and confirm the structures of the impurities in esomeprazole sodium for injection. Method: HPLC method was adopted. The determination was performed on Agilent chromatog. (model: 1260, detector: G1315D), ZORBA EXTEND-C18 (250 mm × 3.0 mm, 5 μm) column was used. The flow rate was 1.0 mL·min-1 with UV detective wavelength at 280 nm, the column temperature was 35°C, gradient elution; the structure was identified by NMR and mass spectrum. Results: The imparity peaks and esomeprazole sodium peak were effectively separated when the sample was forcedly destroyed, no matter change the proportion of mobile phase, column temperature, flow rate, or different chromatog. column models and manufacturers, the separation degree accords with regulation. Conclusion: The method has been developed and validated of the detection and control of impurities in esomeprazole sodium for injection, and the structures of impurities have been confirmed. This method is selective, specific, good durable. It is suitable for structure confirmation, detection and control of impurities in esomeprazole sodium for injection.
Shandong Huagong published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Synthetic Route of 161796-78-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem