Van Gyseghem, E. published the artcileDetermining orthogonal chromatographic systems prior to the development of methods to characterise impurities in drug substances, Product Details of C17H20ClN3, the publication is Journal of Chromatography, A (2003), 988(1), 77-93, database is CAplus and MEDLINE.
To define starting conditions for the development of methods to sep. impurities from the active substance and from each other in drugs with an unknown impurity profile, the parallel application of generic orthogonal chromatog. systems could be useful. The possibilities to define orthogonal chromatog. systems were examined by calculation of the correlation coefficients between retention factors k for a set of 68 drugs on 11 systems, by visual evaluation of the selectivity differences, by principal component anal., by drawing color maps, and evaluating dendrograms. A zirconia-based stationary phase coated with a polybutadiene (PBD) polymer and 3 silica-based phases (base-deactivated, polar-embedded and monolithic) were used. Besides the stationary phase, the influence of pH and of organic modifier, on the selectivity of a system were evaluated. The dendrograms of hierarchical clusters were found good aids to assess orthogonality of chromatog. systems. The PBD-zirconia phase/methanol/pH 2.5 system is found most orthogonal towards several silica-based systems, e.g. a base-deactivated C16-amide silica/methanol/pH 2.5 system. The orthogonality was validated using cross-validation, and 2 other validation sets, i.e. a set of non-ionizable solutes and a mixture of a drug and its impurities.
Journal of Chromatography, A published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C7H16Cl2Si, Product Details of C17H20ClN3.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem