Amer, M. M. published the artcileModified nitroprusside colorimetric determination of antazoline salts in some pharmaceutical preparation, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmazie (1974), 29(5), 354-5, database is CAplus and MEDLINE.
The nitroprusside method of Slack and Mader (1957) was improved by using 80 mg H3BO3 in place of NaHCO3 (to alter pH) and adding 4 ml EtOH to give a red color instead of the violet, measurable at 540 nm, the color being maximum at 1 min and stable for 12 hr. The method is superior to that of BP 1968 and USP XV, since ephedrine and 19 other substances tested did not interfere with the reaction but naphazoline, Zn2+, and phentolamine did,. Recovery by this method ranged between 100.6.+-.0.23% to 102.3.+-.1.2%. Determinations were made against a standard curve for 0.1-1. mg of the corresponding antazoline salt.
Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem