Subbaiah, B. Venkata published the artcilePREPARATIVE ISOLATION AND UPLC-TOF MS IDENTIFICATION OF EIGHT DEGRADANTS FROM STRESSED TABLETS OF ESOMEPRAZOLE, Application In Synthesis of 161796-78-7, the publication is Journal of Liquid Chromatography & Related Technologies (2013), 36(9), 1243-1250, database is CAplus.
Esomeprazole is a proton pump inhibitor, used in the treatment peptic ulcer disease (PUD). Eight degradants were found in the formulated drug under the stress conditions, (40°C/75% Relative Humidity (RH) for 6 mo) with Relative Retention Time’s (RRT’s) 0.26, 0.29, 0.32, 0.59, 0.88, 0.96, 1.12, and 1.33 by a LC-MS compatible method. A simple effective gradient preparative HPLC method was developed with the runtime of 20 min to isolate all the degradants. The degradants were stabilized and identified by UPLC-TOF MS. The method is capable and can be used to isolate further degradants. Supplemental materials are available for this article. Go to the publisher’s online edition of Journal of Liquid Chromatog. and Related Technologies to view the free supplemental file.
Journal of Liquid Chromatography & Related Technologies published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C11H21BF4N2O2, Application In Synthesis of 161796-78-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem