Electric Literature of 31722-49-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31722-49-3, name is 1H-Imidazole-2-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
SYNTHESIS EXAMPLE 1 Synthesis of 2-cyano-1-dimethylsulfamoylimidazole (Compound No. 1) Thirty grams of 2-cyanoimidazole, 53.4 g of anhydrous potassium carbonate and 600 ml of acetonitrile were mixed at room temperature. After reacting for 2 hours at the refluxing temperature, the reaction mixture was cooled, and 55.6 g of dimethylsulfamoyl chloride was added thereto. The mixture was reacted again at the refluxing temperature for 2 hours. After completion of the reaction, the reaction mixture was poured into water. Extraction with methylene chloride was carried out. After washing with water, the extract was dried over anhydrous sodium sulfate. The solvent was removed by distillation. The obtained residue was purified by silica gel column chromatography (developing solvent: methylene chloride) to give 28.0 g of 2-cyano-1-dimethylsulfamoylimidazole (Compound No. 1) having a melting point of from 74 to 76 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Ishihara Sangyo Kaisha, Ltd.; US4995898; (1991); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem