Kayarohanam, Saminathan published the artcileA validated RP HPLC method for the estimation of esomeprazole sodium injection, Product Details of C17H18N3NaO3S, the publication is International Journal of Pharmacy (Hyderabad, India) (2014), 4(2), 183-188, database is CAplus.
Esomeprazole is chem. bis (5methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl]sulfinyl]- 1Hbenzimidazole-1-yl). It is a gastric proton-pump inhibitor (PPI) used in treatment of gastric-acid related diseases. A Simple, sensitive, selective and accurate reverse phase high performance liquid chromatog. (RP-HPLC) methods were developed, estimated and validated for the anal. of Esomeprazole sodium in bulk and injection forms. The chromatog. separation was performed by the using C8, column having 250 × 4.6mm 5μm. Using mobile phase containing Acetonitrile and phosphate buffer (58:42vol./volume) adjusted to PH 7.6 with phosphoric acid. The anal. was run at a flow rate of 1.5ml/min and injection volume was 20 μL. The detection was monitored at 280nm. The retention time of Esomeprazole was 2.93 min. The developed method was validated for precision, intermediate precision (ruggedness), linearity, specificity, accuracy, and stability. Recovery of Esomeprazole in formulations was found to be in the range of 99.08%, 100.86%, and 101.52% resp. And the correlation coefficient was 0.999. Hence, it was concluded that the developed method is suitable for routine anal. due to its less anal. time.
International Journal of Pharmacy (Hyderabad, India) published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Product Details of C17H18N3NaO3S.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem