Lipi, Farhana published the artcileDevelopment and validation of analytical method for determination of esomeprazole sodium by HPLC, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is International Research Journal of Pharmacy (2016), 7(5), 10-14, database is CAplus.
A very simple, accurate, specific, precise and rapid reverse phase high performance liquid chromatog. technique has been built up as well as validated to determine the Esomeprazole Sodium. The method is applicable for the quant. anal. of the drug substance. Chromatog. seperation was achieved on a Supelco 250-mm, 4.6-mm, and 5-μ m C-18 anal. column with a mixture of Buffer and Acetonitrile at a volume ratio of 55:45 (volume/volume) as mobile phase at a flow rate of 1.0 mL/min. The mol. eluted within a short runtime (within 7.0 min). The eluted compound was monitored at a detector wavelength of 302 nm and the column oven temperature was maintained at 25°C. The developed method was validated according to ICH guidelines. The high recovery and low relative standard deviation confirm the suitability of the method for detection of Esomeprazole Sodium. The repeatability and intermediate precision, expressed by the % RSD, were less than 2%. Accuracy (% recovery: 98.00-102.00%) was found to satisfactory. The method was validated by determining its accuracy, precision, system suitability, linearity and robustness. Validation studies reveal that the method is simple, specific, rapid, reproducible, precise and accurate, which is useful for the routine detection of Esomeprazole Sodium.
International Research Journal of Pharmacy published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem