Indolent T cell lymphoma involving the central nervous system and successfully treated by bendamustine was written by Hui, Min;Chen, Miao. And the article was included in Annals of Hematology in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:
Peripheral T-cell lymphoma, not otherwise unspecified (PTCL-NOS), was most common among the peripheral T-cell lymphomas (PTCL) subtypes. The central nervous system (CNS) is rarely involved as the primary site, making it especially challenging for diagnosis and treatment. The present report describes a rare case of indolent PTCL involving the central nervous system, bone marrow, s.c. tissue, and muscles, which was successfully treated by the bifunctional alkylating agent bendamustine and allogeneic hematopoietic stem cell transplantation. This report describes the first known experience of patients with indolent T cell lymphoma involving the central nervous system treated with bendamustine. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem