Treatment of relapsed/refractory follicular lymphoma was written by Fukuhara, Noriko. And the article was included in Ketsueki Naika in 2021.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:
A review. Follicular Iymphoma (FL) is a typical type of so-called indolent lymphoma that progresses on a yearly basis, accounting for about 20% of all B-cell lymphoma, and has increased in recent years in Japan as well as in Europe and the United States. In the normal recurrence group, there is no change in transformation, and most of the transformation is DLBCLNOS, but high grade Iymphoma with MYC locus is also observed in some cases. At that point, it will be necessary to further elucidate the pathophysiol. of follicular lymphoma with the new treatment opening 56 in order to judge the situation and select a better move. The addnl. effect of obinutuzumab on bendamustine therapy is verified in the case of rituximab resistance. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem