A common compound: 98873-55-3, name is 2-(1H-Imidazol-1-yl)acetonitrile, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 98873-55-3
A 10 mL schienk tube was charged with powdered KOH (116 mg, 2.07 mmol), DMSO (1 mL), purged with Argon and cooled at 18CC with a water bath. A solution of 2-imidazol-1- ylacetonitrile (104 mg, 0.97 mmol) and CS2 (117 pL, 1.9408 mmol) in DMSO (500 pL) is then added slowly to give an orange mixture. The cooling bath is removed and the reaction is stirred at room temperature for 30 minutes. Then a solution of freshly prepared (2-bromo-5-fluoro-indan-1-yl)methanesulfonate (step 3) in DMSO is added dropwise. After 30 minutes stirring at room temperature, the reaction is poured into H20 (20 mL). The aqueous phase is extracted with AcOEt (3 x 5 mL), the combined organic phases were washed with H20 (10 mL), brine (10 mL), dried with Mg504, filtered and evaporated to give a crude pale yellow residue. Purification by chromatography on silica gel (heptanes/ethylacetate 2:1-1:3) afford2-(6-fluoro-4,8b-dihydro-3aH-indeno[1 ,2-d][1 ,3]dithiol-2-ylidene)-2-imidazol-1 -yl-acetonitrile as an inseparable (2:1) mixture of E/Z-isomers.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 98873-55-3, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; GAGNEPAIN, Julien, Daniel; BONVALOT, Damien; JEANMART, Stephane, Andre, Marie; WO2015/11194; (2015); A1;,
Imidazole – Wikipedia,
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