Application of 20485-43-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 101-4; N- [3- ( {2- [ (cyclopropylcarbonyl) amino] [1,3] thiazolo [5, 4-b] pyridin- 5-yl } oxy) phenyl] -l-methyl-lH-imidazole-2-carboxamide; A mixture of N- [5- (3-aminophenoxy) [1, 3] thiazolo [5, 4- b]pyridin-2-yl] cyclopropanecarboxamide (175 mg, 0.536 mmol) , 1- methyl-lH-imidazole-2-carboxylic acid (101 mg, 0.804 mmol), HATU (367 mg, 0.965 mmol), N,N-diisopropylethylamine (420 muL, 2.41 mmol) and N,N-dimethylformamide (5 mL) was stirred at room temperature for 15 hr. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography (silica gel, hexane/ethyl acetate=50/50->0/100) and recrystallized from ethyl acetate-tetrahydrofuran to give the title compound (152 mg, 65%) as a white solid. 1H-NMR (DMSO-d6, 300 MHz) delta 0.94 – 1.01 (4H, m) , 1.95 – 2.04 (IH, m) , 3.97 (3H, s) , 6.86 – 6.91 (IH, m) , 7.07 – 7.15 (2H, m) , 7.38
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/150015; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem