Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., name: 2-Phenyl-1H-imidazole-4-carbaldehyde
COMPOUND 12. 1.34 : 1- (DIETHYLAMINO) CARBONYUPHENYL-2-rC2- PHENYL-1-IMIDAZOL-5-YL) METHYL]-L24- TETRAHYDROISOQUINOLIN-6-YL METHANESULFONATE; INTERMEDIATE 6.4. 1 (27 mg, 0.067 mmol) and 2-phenyl-4 (5)- imidazolecarbaldehyde (23 mg, 0.134 mmol) were dissolved in 1,2-dichloroethane (3.0 mL) and sodium triacetoxyboronhydride (43 mg, 0.20 mmol) was added. The mixture was stirred for 18 h after which ethyl acetate and 1 M sodium hydroxide solution were added. After phase separation the aqueous phase was extracted with more ethyl acetate and the combined organic phases were washed with water and brine. Tosylhydrazine resin (100 mg, 1.5 mmol/g) was added and the mixture was stirred for 2 h. After filtration and thorough washing of the resin the filtrate was evaporated and the residue was purified by flash chromatography the product (36 mg (0.064 mmol, 96%). 1H NMR (500 MHz, CDC13) : 1.13, 1.27 (2 brs, 6H), 2.64, 2. 82, 3.10, 3.12 (4 m, 4H), 3.11 (s, 3H), 3.28, 3.56 (2 brs, 4H), 3.45, 3.56 (2 d, J 12. 0 Hz, 2H), 4. 68 (s, 1H), 6.68 (d, 8.5 Hz, 1H), 6.86 (s, 1H), 6.90 (dd, J 8.5, 2.0 Hz, 1H), 7.05 (d, J 2.0 Hz, 1H), 7.34 (m, 7H), 7.89 (d, J 7.5 Hz, 2H). (+) LRESIMS m/z 559 (100) [M+H] +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem