Rabeprazole-amoxicillin dual therapy as first-line treatment for H pylori eradication in special patients: A retrospective, real-life study was written by Gao, Wen;Ye, Hui;Deng, Xin;Wang, Chi;Xu, Ying;Li, Yixuan;Zhang, Xuezhi;Cheng, Hong. And the article was included in Helicobacter in 2020.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:
The currently recommended quadruple regimens for Helicobacter pylori infection might not be appropriate for every patient, especially in elderly patients or those with multiple comorbidities. To evaluate the efficacy and safety of rabeprazole amoxicillin dual therapy in H pylori-pos. elderly patients or those with multiple comorbidities. From Nov. 2013 to May 2017, the clin. data of H pylori pos. patients 鈮?0 years old or with multiple comorbidities were collected and reviewed. All patients were given rabeprazole 10 mg three times a day and amoxicillin 1000 mg thrice a day (RA dual therapy) for 14 days as first line treatment. H pylori eradication was evaluated by 13C urea breath test 6 wk after treatment. Adverse effects were recorded. A total of 198 patients were enrolled, including 116 elderly patients and 82 patients with multiple comorbidities. Successful eradication was achieved in 90.9% (180/198, 95% CI: 86.1%-94.2%) patients. Adverse effects, which were mainly mild (referring to skin rash, abdominal pain, and diarrhea), occurred in 22 patients (22/198, 11.1%) and resolved spontaneously. Dual therapy composed of rabeprazole and amoxicillin as a first line treatment appears to be effective and safe for H pylori infection in elderly patients or those with multiple comorbidities. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem