Zhu, Mingchang et al. published their research in Applied Organometallic Chemistry in 2019 | CAS: 1374155-84-6

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 3,5-Di(1H-imidazol-1-yl)pyridine

Isomeric Effect on the anticancer Behavior of two Zinc(II) complexes based on 3,5-bis(1-imidazolyl)pyridine: Experimental and Theoretical Approach was written by Zhu, Mingchang;Song, Da;Liu, Ning;Wang, Kehua;Su, Junqi;Xiong, Meng;Zhang, Xi;Xu, Yuang;Gao, Enjun. And the article was included in Applied Organometallic Chemistry in 2019.Name: 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

Two isomeric Zinc(II) complexes constructed by 3,5-bis(1-imidazolyl)pyridine has been synthesized and characterized by single crystal x-ray diffraction, elemental analyses and IR spectroscopy. The binding mode and ability of complex 1–2 with CT-DNA were studied by UV and fluorescence spectra. The intrinsic binding constant Kb (Kb1 = 2.305 脳 104 M-1, Kb2 = 3.095 脳 104 M-1) and the observed association constant Kobs (Kobs1 = 1.523*106 M-1, Kobs2 = 2.057*106 M-1) indicated that the insertion ability of complex 2 with CT-DNA is stronger than complex 1. Gel electrophoresis showed that complexes have a good ability to hydrolyze cleavage pBR322 plasmid DNA. The cytotoxicity and apoptosis studies showed that complexes exhibited excellent cytotoxic activity against HeLa cells, especially complex 2 had better growth inhibition than Cisplatin. Mol. docking study simulated the binding model of complexes with DNA (PDB:4av1), showing an imidazole plane of complex 2 can be inserted into a DNA base pair in relative parallel. Both complexes can be used as potential anticancer agents. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Name: 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem