Fabrication of pH-Responsive Hydrogel and Its In Vitro and In Vivo Evaluation was written by Tulain, Ume Ruqia;Ahmad, Mahmood;Rashid, Ayesha;Malik, Muhammad Zubair;Iqbal, Furqan Muhammad. And the article was included in Advances in Polymer Technology in 2018.Related Products of 117976-90-6 The following contents are mentioned in the article:
The present research work deals with the development of pH-responsive hydrogel by free radical polymerization in aqueous media to protect the rabeprazole sodium from acidic environment of stomach. Swelling behavior of hydrogels that was observed in buffer of various pH indicated highly pH-dependent swelling of hydrogels. Characterization of pH-responsive hydrogels by FTIR, SEM, and thermal anal. revealed that hydrogel has porous structure, favors swelling, drug loading, and drug release at a specific site in gastrointestinal tract and thermally more stable than parent polymer. In comparison with simple drug solution and hydrogel formulations, pharmacokinetic parameters of hydrogels formulations showed a significant difference in Cmax values of (CMC-g-AA) CA and the same oral dose of rabeprazole sodium was 87.28 卤 12.671 and 61.263 卤 5.37 ng/mL, resp., Tmax of graft copolymer matrixes CA (4.43 h) was significantly (P < 0.05) higher than drug solution (1 h) and area under curves (AUCs) for CA (952.25 卤 191 ng路/mL) was significantly (P < 0.05) higher than the drug solution (83.67 卤 8.28 ng路/mL) indicated the effect of dosage form would last for longer duration. Thus, in vitro and in vivo drug release studies of hydrogels proved their controlled release behavior with preferential delivery into alk. pH environment and for a prolonged period of time. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Related Products of 117976-90-6).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 117976-90-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem