Pantoprazole, a proton-pump inhibitor, impairs human sperm motility and capacitation in vitro was written by Escoffier, Jessica;Arnaud, Bastien;Kaba, Mayis;Hograindleur, Jean Pascal;Le Blevec, Emilie;Martinez, Guillaume;Stevant, Isabelle;Ray, Pierre F.;Arnoult, Christophe;Nef, Serge. And the article was included in Andrology in 2020.Formula: C18H20N3NaO3S The following contents are mentioned in the article:
Background : The effects of PPIs on human sperm fertilizing capacity were poorly investigated although these drugs are widely over-used. Objectives : Do PPIs, which are among the most widely sold drug in the word, impact neg. human sperm capacitation and sperm motility Materials and methods : The effects of PPIs on human sperm maturation and motility were analyzed by CASA, flow cytometry, and Western blot. Results : We tested the impact of 6 different PPIs on human sperm motility and capacitation. We showed that pantoprazole, but not the other PPIs, decreased sperm progressive motility and capacitation-induced sperm hyperactivation. We therefore investigated further the effects of pantoprazole on sperm capacitation, and we observed that it had a significant deleterious effect on the capacitation-induced hyperpolarization of the membrane potential and capacitation-associated protein phosphorylation. Discussion and Conclusion : Our results indicate that exposure to pantoprazole has an adverse effect on the physiol. competence of human spermatozoa. As the capacitation process takes place within the female tract, our results suggest that PPIs intake by the female partner may impair in vivo sperm maturation and possibly fertilization. Moreover, the absence of adverse effect by PPIs on mouse sperm emphasizes the need to develop reprotox assays using human material to better assess the effects of medication intake on sperm physiol. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Formula: C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem