Does Rabeprazole Sodium Alleviate the Anti-diabetic Activity of Linagliptin Drug-Drug Interaction Analysis by In vitro and In vivo Methods was written by Hossain, Jamal Md.;Sultan, Zakir Md.;Rashid, Mohammad A.;Kuddus, Ruhul Md.. And the article was included in Drug Research (Stuttgart, Germany) in 2020.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:
Drug interaction has turned into the preeminent regarding issues for a prescriber during polypharmacy. The foremost objective of this research was to form a complex between linagliptin and rabeprazole sodium by in vitro interactions. The interactions between the drugs have been examined by monitoring some chromatog. and spectroscopic analyses viz. TLC, HPLC, FT IR, UV, Job’s plot, conductometric titrations, and Ardon’s spectrophotometric strategy. Rabeprazole sodium formed a stable complex with linagliptin, which was ensured from the insight of these anal. data. The retention time (R t) of the formed complex was 5.303 min, where the R twere 3.364 and 3.103 min for linagliptin and rabeprazole sodium, resp., in HPLC chromatograms. In FT IR and UV spectra of the formed complex revealed some disappearance of characteristic peaks that affirmed the complexation. All of the variations of the spectrophotometric and chromatog. properties from the antecedent drugs indicated the drug drug interaction. The assessment of anti diabetic property on alloxan induced Swiss albino mice proved significant in vivointeraction between the drugs. Animal study that the hypoglycemic activity of linagliptin might be significantly affected due to the complex formation of the drug with a proton pump inhibitor (PPI). It is the primary outcome of the interaction, which recommends the bigger in vivostudy or clin. monitoring on the human model. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem