Effects of bifidobacterium triplex capsule combined with quadruplex therapy on the level of inflammation-oxidative stress in Hp positive chronic superficial gastritis was written by Zhai, Qi;Chen, Yingjie;Xuan, Jie;Wen, Wei;Hu, Weijie. And the article was included in Guizhou Yike Daxue Xuebao in 2020.Computed Properties of C18H20N3NaO3S The following contents are mentioned in the article:
Objective: To investigate the efficacy of bifidobacterium triple viable capsules combined with quadruple therapy for patients with Helicobacter. pylori (Hp)-pos. chronic superficial gastritis and effects on inflammation-oxidative stress. Methods: From Jan. 2017 to Oct. 2018, 152 patients with Hp-pos. CSG who admitted to our department were enrolled and randomly assigned to the observation group and the control group, with 76 cases in each group. Both groups were treated conventionally. The control group received standard quadruple therapy (rabeprazole sodium enteric coated capsule + colloidal pectin bismuth dry suspension + clarithromycin sustained release tablets + amoxicillin dispersible tablets), the observation group received bifidobacteria triple viable capsules therapy on the basis of the control group, the course of treatment was 2 mo for both groups. At the end of treatment, the clin. efficacy and Hp eradication were compared between the two groups. Serum inflammation indicators [interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α)] and oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH-Px)] were detected before and after treatment. Results: The total effective rate and Hp eradication rate of the observation group were 98.68% and 89.47%, higher than 88.16%, 69.74% of the control group (P<0.05). After treatment, the serum levels of NF-κB, IL-4, IL-6, IL-8, TNF-α and MDA in the observation group were lower than those in the control group, while IL-10, SOD and GSH-Px were higher than the control group (P<0.05). After 6 mo of follow-up, the recurrence rate of the observation group was 10.67%, which was lower than 26.87% of the control group (P<0.05). Conclusion: Bifidobacterium triple viable capsules combined with quadruple therapy for the treatment of Hp-pos. CGS is effective, which can inhibit inflammation and oxidative stress damage and reduce the risk of recurrence. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Computed Properties of C18H20N3NaO3S).
Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C18H20N3NaO3S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem