Durant, Graham J. published the artcilePotential histamine H2-receptor antagonists. 3. Methylhistamines, Category: imidazoles-derivatives, the publication is Journal of Medicinal Chemistry (1976), 19(7), 923-8, database is CAplus and MEDLINE.
Syntheses are described for all mono-, and some di- and trimethylhistamines, including the novel compounds β-methyl- (I) [24160-35-8], 4,Nα-dimethyl- (II) [36376-52-0], and 4,Nα,Nα-trimethylhistamine-2HCl (III) [54732-97-7], and agonist activities reported for stimulation of histamine [51-45-6] H1 (guinea-pig ileum) and H2 (rat gastric acid secretion) receptors. H2 receptor agonist activities indicated substantial retention of receptor binding for 4-methylhistamine-2 HCl (IV) [36376-47-3] and Nα-methylhistamine-2HCl (V) [16503-22-3]. Structure in relation to potential histamine receptor antagonists was discussed.
Journal of Medicinal Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Category: imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem