Sanghavi, N. M. published the artcileEstimation of antazoline hydrochloride in tablets of antazoline hydrochloride, Related Products of imidazoles-derivatives, the publication is Indian Journal of Pharmacy (1974), 36(6), 137-8, database is CAplus.
The method of estimation of antazoline-HCl [2508-72-7] in tablets was based on the formation of a stable yellow nitroso derivative with NaNO2 solution in the presence of dilute HCl which shows maximum absorption at 412 mμ. A graph of optical d. against concentration gave a straight line over a concentration range of 10 μg/ml to 50 μg/ml showing that the reaction was in compliance with Beer’s Law. Known amounts of antazoline-HCl were added to known amounts of previously analyzed samples of antazoline-HCl and analyzed again by the proposed method. The percentage recovery was 98.6. The proposed method was found to be satisfactory within a narrow range of ± 2%. It was also found that other antihistamines like chlorpheniramine [132-22-9], dimenhydrinate [523-87-5], diphenhydramine [58-73-1] did not interfere. Excipients like starch [9005-25-8], gum arabic [9000-01-5], magnesium stearate [557-04-0], etc. did not interfere while paracetamol [103-90-2], phenylephrine-HCl [61-76-7] interfered.
Indian Journal of Pharmacy published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem