Bertolasi, V.’s team published research in Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry in B38 | CAS: 2508-72-7

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.

Bertolasi, V. published the artcileCrystallographic and conformational studies on histamine H1 receptor antagonists. III. Antazoline hydrochloride, Computed Properties of 2508-72-7, the publication is Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry (1982), B38(9), 2522-5, database is CAplus.

The title compound is monoclinic, space group I2/c, with a 25.819(5), b 5.917(3), c 21.549(4) Å, and β 104.30(3)°; dc = 1.26 for Z = 8. The structure was refined to R = 0.041. The at. parameters, bond angles and distances are given. Comparison of the present and previous crystal-structure determinations seems to substantiate the idea that a distance of 6.00-6.40 Å between the amino N and the center of gravity of 1 unsaturated ring is the main requirement to be fulfilled for the mol. to display antihistaminic activity.

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem