Asempa, Tomefa E. published the artcilePhysical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration, Safety of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is American Journal of Health-System Pharmacy (2018), 75(14), 1048-1056, database is CAplus and MEDLINE.
The results of a study to determine the phys. compatibility of plazomicin sulfate solution during simulated Y-site administration with 92 i.v. drugs are reported. Plazomicin injection solution (500 mg/10 mL) was diluted in 0.9% sodium chloride or 5% dextrose for injection to a final volume of 50 mL (final plazomicin concentration, 24 mg/mL), consistent with a 15-mg/kg dose administered to an 80-kg patient (i.e., 1,200 mg). All other i.v. drugs were reconstituted according to manufacturers’ recommenda- tions and diluted with 0.9% sodium chloride or 5% dextrose for injection to the upper range of concentrations used clin. Y-site conditions were simulated by mixing 5 mL of plazomicin solution with 5 mL of tested drug solutions in a 1:1 ratio. Solutions were assessed for visual (via color and Tyndall beam testing), turbidity (using a laboratory-grade turbidimeter), and pH changes over a 60-min observation period. Incompatibility was defined a priori as precipitation, color change, a pos. Tyndall test, or a turbidity change of â?.5 nephelometric turbidity units at any time during the 60-min observation period. Plazomicin was phys. compatible with 79 of the 92 drugs tested. Determinations of phys. incompatibility with plazomicin were made for 13 drugs: albumin, amiodarone, amphotericin B deoxycholate, anidulafungin, calcium chloride, daptomycin, esomeprazole, heparin, le- vofloxacin, methylprednisolone, micafungin, phenytoin, and propofol, Conclusion. Plazomicin at a concentration of 24 mg/mL was phys. compatible with 85% of the drugs tested, including 31 of 36 antimicrobial agents.
American Journal of Health-System Pharmacy published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Safety of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.
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