Ranganathan, Darshan published the artcileRepetitive imidazole synthesis using an immobilized imidazole template, HPLC of Formula: 21343-04-4, the main research area is imidazole repetitive synthesis template; ATP imidazole cycle model.
A model is presented for the chem. simulation of the ATP-imidazole cycle programmed to continuous production of the daughter imidazoles from the immobilized parent imidazole template. 6-Chloropurine was treated with chloromethylated polystyrene and hydrolysis of the product followed by alkylation with PhCOCH2Br afforded polymer-bound hypoxanthine I (R = CH2COPh, R1 = chloromethylated polystyrene). Treating I (R = CH2COPh, R1 = chloromethylated polystyrene) with PhCH2NH2 and p-MeC6H4SO3H produced the expected daughter mol., 1-benzyl-5-phenylimidazole (II) in 30% yield and the polymer-bound 5-aminoimidazole-4-carboxamide III, which, in turn, was transformed to the template hypoxanthine I (R = H) by treatment with MeSO3H followed by HCONH2. To prove the concept of the continuous generation of the daughter mol., the regenerated parent template was processed through a second cycle using the same protocol when the expected daughter product II was obtained in 14% yield. Polymer-bound adenine when subjected to a similar protocol failed to yield any daughter mol. Endeavors to prepare polymer-linked 4-oxoquinazoline and anthranilic acid are also reported.
Journal of Organic Chemistry published new progress about imidazole repetitive synthesis template; ATP imidazole cycle model. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, HPLC of Formula: 21343-04-4.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem