Kim, Mi Kyoung published the artcile3D-QSAR of PET agents for imaging β-amyloid in Alzheimer’s disease, SDS of cas: 1023-01-4, the main research area is beta amyloid PET imaging agent QSAR model; thioflavin stilbene derivative amyloid plaque imaging QSAR.
The accumulation of excess senile plaques (β-amyloid, Aβ-plaques) in the brain is strongly associated with the pathogenesis of Alzheimer’s disease (AD). While there are no definitive treatments available to affect a cure of AD, much recent interest has been given to the development of antiamyloid therapies aimed at halting and reversing Aβ-deposition and, thus, monitoring of the therapeutic efficacy would greatly benefit from methods for the in vivo detection and quantification of Aβ-deposits in the brain. A 3D-QSAR model was constructed with several PET ligands such as Thioflavin-T analogs and stilbene derivatives using CoMFA (Comparative Mol. Field Anal.) and CoMSIA (Comparative Mol. Similarity Indexes Anal.). The 3D-QSAR model could be applied to predict binding affinity of the structurally related compounds against Aβ-plaques.
Bulletin of the Korean Chemical Society published new progress about Affinity. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, SDS of cas: 1023-01-4.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem