Clark, Jim’s team published research in Journal of the Chemical Society [Section] C: Organic in 1971 | CAS: 274-78-2

Journal of the Chemical Society [Section] C: Organic published new progress about Cyclization. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Quality Control of 274-78-2.

Clark, Jim published the artcileHeterocyclic studies. XVI. Imidazo and diimidazopyrimidines, Quality Control of 274-78-2, the main research area is imidazopyrimidines; diimidazopyrimidines; pyrimidines imidazo.

Condensation of 2,4-dichloro-6-methyl-5-nitropyrimidine (I, X = Cl) with Cl(CH2)2NH2 gave the tetrahydrodiimidazopyrimidine (II). A hydrated derivative (III) of II was prepared by POCl3 treatment of either the 2,4-bis[(2-hydroxyethyl)amino]pyrimidine (I, X = NH(CH2)2OH), the dihydroimidazo[1,2-a]pyrimidine [IV, R1 = Me, R2 = NH(CH2)2OH] or the dihydroimidazo[1,2-a]pyrimidine (V). 4,6-Dichloro-2-methyl-5-nitropyrimidine (VI, X = Cl) and Cl(CH2)2NH2 gave the bis[(2-chloroethyl)amino]-pyrimidine (VI, X = NH(CH2)2Cl), which cyclized in two steps to the dihydroimidazo[1,2-c]pyrimidine [IV, R1 = NH(CH2)2Cl, R2 = Me] and then the quaternary tricyclic compound (VII).

Journal of the Chemical Society [Section] C: Organic published new progress about Cyclization. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Quality Control of 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem