Dumanovic, D. published the artcileSimultaneous determination of N-substituted and N-substituted nitroazoles, and criteria for their identification. III. Chromatographic separation and polarographic determination of halonitroimidazoles, Name: 5-Bromo-2-methyl-4-nitroimidazole, the main research area is halonitroimidazole mixture polarog chromatog; chromatog thin layer halonitroimidazole; nitroimidazole halo polarog determination; imidazole halo nitro determination.
Halonitroimidazoles with the NO2 group in the same position are separated for identification by thin-layer chromatog. on unactivated silica gel HF254 in an atm. saturated with the vapor of 1 of 5 developers, the plate then being sprayed with 15% SnCl2 solution in aqueous HCl, dried, sprayed with p-dimethylaminobenzaldehyde solution, and redried. All 4-nitro derivatives give a yellow color and 4(5)- and 5-nitro compounds are yellow-red. Polarog. determination of halonitroimidazoles may be used in all synthetic processes where the azoles were prepared by nitration of haloimidazoles. A sample of the reaction mixture containing ≤10-3M polarog.-active compound and a suitable buffer is polarographed in the presence and absence of 2 ml 10-3M standard solution of the imidazole being determined and the amount imidazole is directly calculated from the observed wave heights. For halonitroimidazoles obtained from 5(4)-halo-4(5)-nitroimidazoles by substitution of the imino H, and when only one N-substituted derivative is present in the reaction mixture, simultaneous polarog. determination of both compounds is possible only in alk. medium. For mixtures on which simultaneous polarog. determination is impossible a sample of the reaction mixture containing 3 × 10-3-10-2M of all polarog.-active compounds is chromatog. separated and the bands are removed, dissolved in water, and then polarographed.
Talanta published new progress about Chromatography. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Name: 5-Bromo-2-methyl-4-nitroimidazole.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem