Linz, Sabine published the artcileDesign, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases, Category: imidazoles-derivatives, the main research area is dopamine D4 receptor antagonist Mannich bases SAR preparation.
A series of phenylpiperazine-methyl-substituted 1H-pyrrolo[2,3-c]pyridine, imidazo[1,2-c]-, pyrrolo[2,3-d]- and pyrrolo[3,2-d]pyrimidines were prepared as selective dopamine D4-ligands. The pyrrolo[2,3-d]pyrimidine derivatives 12d (I) (K i = 1,9 nM) and 34d (II)(K i = 2,4 nM) as well as the pyrrolo[3,2-d]pyrimidine Mannich base 49f (III) (K i = 2,8 nM) showed high dopamine D4 receptor activity superior to the atypical antipsychotic agent clozapine.
Bioorganic & Medicinal Chemistry published new progress about Antipsychotics. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Category: imidazoles-derivatives.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem