Electric Literature of 760212-58-6,Some common heterocyclic compound, 760212-58-6, name is 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, molecular formula is C19H13BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In one 250 mL flask, 2.4 g (5.00 mmol) of Int.16, 1.9 g (5.50 mmol) of intermediate (13) 0.06 g (0.50 mmol) of Pd(PPh3)4, 0.7 g (12.5 mmol) of K2CO3, 50 mL of toluene, 25 mL of EtOH and 25 mL of H2O were mixed and then refluxed. After the reaction is complete, cool to room temperature and add 200 mL H2O. The mixture was extracted twice with 300 mL of dichloromethane (DCM), the extract was dried with Na2SO4, filtered and the filtrate was concentrated under reduced pressure. The solid was dissolved in chloroform and purified by silica gel column chromatography (dichloromethane (DCM) / ethyl acetate (EA)). Solidification with dichloromethane (DCM) / n-hex and filtration gave 1.3 g (yield: 43.3%) of compound 4-418 (WS16-30-067) as a beige solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, its application will become more common.
Reference:
Patent; Raepto Co., Ltd.; Kim Gyu-ri; Go Byeong-su; Kim Hye-jeong; Ryu Yong-jae; Im Cheol-su; Park Yong-pil; Yoon Jeong-hun; Han Gap-jong; Oh Yu-jin; (85 pag.)KR2017/142950; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem