In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H8N2O
COMPOUND 12.1. 10: N,N-DIETHYL-4-{6-METHOXY-2-[(2-PHENYL-1H- IMIDAZOL-5-YL) METHYL1-1, 2, 3, 4-TETRAHYDROISOQUINOLIN-1- YUBENZAMIDE; INTERMEDIATE 5.1. 7 (15 mg, 0.04 mmol) and 2-phenyl-4 (5)- imidazolecarbaldehyde (20 mg, 0.12 mmol) were dissolved in DCE (2 mL). After stirring for 10 min at room temperature, sodium triacetoxyborohydride (34 mg, 0.16 mmol) was added and the mixture was stirred for 18 h at room temperature. DCM and 1 M sodium hydroxide solution were added and the mixture was passed through a Whatman 1PS silicon-treated filter paper. The organic phase was evaporated and the crude product was purified by flash chromatography to yield the product (80 mg, 0.016 mmol, 77%). 1H NMR (500 MHz, CDCl3) : 1.05, 1.15 (2 brs, 6H), 3.10-3. 35 (m, 4H), 3.40-3. 65 (m, 4H), 3.68 (s, 3H), 3.82 (m, 2H), 5.82 (s, 1H), 6.55-6. 82 (m, 4H), 7.30-7. 77 (m, 6H), 7.98 (d, J 9 Hz, 1H), 8. 32 (d, J 2.5 Hz, 2H). (+) LRESIMS m/z 493 [M+H]+.
The synthetic route of 68282-47-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem