Liu, Mengya; Sun, Zhan-Li; Zeng, Zhigang; Lam, Kin-Man published an article in 2022, the title of the article was MGF6mARice: prediction of DNA N6-methyladenine sites in rice by exploiting molecular graph feature and residual block.Quality Control of N-Methyl-7H-purin-6-amine And the article contains the following content:
DNA N6-methyladenine (6mA) is produced by the N6 position of the adenine being methylated, which occurs at the mol. level, and is involved in numerous vital biol. processes in the rice genome. Given the shortcomings of biol. experiments, researchers have developed many computational methods to predict 6mA sites and achieved good performance. However, the existing methods do not consider the occurrence mechanism of 6mA to extract features from the mol. structure. In this paper, a novel deep learning method is proposed by devising DNA mol. graph feature and residual block structure for 6mA sites prediction in rice, named MGF6mARice. Firstly, the DNA sequence is changed into a simplified mol. input line entry system (SMILES) format, which ref lects chem. mol. structure. Secondly, for the mol. structure data, we construct the DNA mol. graph feature based on the principle of graph convolutional network. Then, the residual block is designed to extract higher level, distinguishable features from mol. graph features. Finally, the prediction module is used to obtain the result of whether it is a 6mA site. By means of 10-fold cross-validation, MGF6mARice outperforms the state-of-the-art approaches. Multiple experiments have shown that the mol. graph feature and residual block can promote the performance of MGF6mARice in 6mA prediction. To the best of our knowledge, it is the first time to derive a feature of DNA sequence by considering the chem. mol. structure. We hope that MGF6mARice will be helpful for researchers to analyze 6mA sites in rice. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Quality Control of N-Methyl-7H-purin-6-amine
The Article related to dna n methyladenine mol graph rice, dna n6-methyladenine, dna molecular graph feature, smiles, residual block, rice genome, Placeholder for records without volume info and other aspects.Quality Control of N-Methyl-7H-purin-6-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem