On December 31, 2021, Bataglia, L.; Simoes, Z. L. P.; Nunes, F. M. F. published an article.Electric Literature of 443-72-1 The title of the article was Active genic machinery for epigenetic RNA modifications in bees. And the article contained the following:
Epitranscriptomics is an emerging field of investigation dedicated to the study of post-transcriptional RNA modifications. RNA methylations regulate RNA metabolism and processing, including changes in response to environmental cues. Although RNA modifications are conserved from bacteria to eukaryotes, there is little evidence of an epitranscriptomic pathway in insects. Here we identified genes related to RNA m6A (N6-methyladenine) and m5C (5-methylcytosine) methylation machinery in seven bee genomes (Apis mellifera, Melipona quadrifasciata, Frieseomelitta varia, Eufriesea mexicana, Bombus terrestris, Megachile rotundata and Dufourea novaeangliae). In A. mellifera, we validated the expression of methyltransferase genes and found that the global levels of m6A and m5C measured in the fat body and brain of adult workers differ significantly. Also, m6A levels were differed significantly mainly between the fourth larval instar of queens and workers. Moreover, we found a conserved m5C site in the honeybee 28S rRNA. Taken together, we confirm the existence of epitranscriptomic machinery acting in bees and open avenues for future investigations on RNA epigenetics in a wide spectrum of hymenopteran species. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Electric Literature of 443-72-1
The Article related to apis melipona epigenetic rna modification methyltransferase 28s rrna, apis mellifera, rna methylation, bee, epitranscripitomics, m5c, m6a, Placeholder for records without volume info and other aspects.Electric Literature of 443-72-1
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