Wright, Jeremy; Frank, Lesley R.; Bush, Donna; Harrison, George H. published an article in 1983, the title of the article was Evaluation of nitrobenzimidazoles as hypoxic cell radiosensitizers.Safety of 2-Nitro-1H-benzo[d]imidazole And the article contains the following content:
Radiobiol. and pharmacokinetic assays were performed to determine the potential of 2-nitrobenzimidazole (NBI) as a hypoxic cell radiosensitizing agent. As judged by comparing survival curve slopes of Serratia marcescens irradiated under aerated and hypoxic conditions, the NBI enhancement ratio (ER) at 2 mM concentration was 2.4, compared with an O enhancement ratio of 3.3. 2,5-Dinitrobenzimidazole (DNBI) was investigated in vitro; its ER was 3.0 at 4 mM concentration Very poor tissue penetration of DNBI precluded further testing in vivo. Acute toxic signs appeared in C3H/HeJ mice following i.p. injection of NBI at 100 mg/kg. These would be partly attributable to the stress caused by the high pH of the injection vehicle. The LD50 was estimated to be 125-150 mg/kg. Mammary adenocarcinoma tumors grown in the flanks of these mice exhibited maximum NBI levels at 5 min postinjection (i.p.). Peak tumor radiosensitization occurred in the interval of 5-10 min postinjection. The ER for tumor regrowth delay was 2.1 following 50 mg/kg injected into mice 5 min before irradiation Functional evaluation up to 40 days after treatment revealed no evidence of neurol. deficit. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Safety of 2-Nitro-1H-benzo[d]imidazole
The Article related to radiosensitization nitrobenzimidazole, Radiation Biochemistry: Other and other aspects.Safety of 2-Nitro-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem