On October 15, 2008, Carlton, David L.; Collin-Smith, Lissa J.; Daniels, Alejandro J.; Deaton, David N.; Goetz, Aaron S.; Laudeman, Christopher P.; Littleton, Thomas R.; Musso, David L.; Morgan, Ronda J. Ott; Szewczyk, Jerzy R.; Zhang, Cunyu published an article.Electric Literature of 73590-85-9 The title of the article was Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead. And the article contained the following:
Starting from a weak omeprazole screening hit, replacement of the pyridine with a 1,3-benzodioxole moiety, modification of the thioether linkage, and substitution of the benzimidazole pharmacophore led to the discovery of nanomolar BRS-3 agonists. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9
The Article related to bombesin receptor brs3 agonist preparation structure activity, Pharmacology: Structure-Activity and other aspects.Electric Literature of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem