Alriquet, Marion; Calloni, Giulia; Martinez-Limon, Adrian; Ponti, Riccardo Delli; Hanspach, Gerd; Hengesbach, Martin; Tartaglia, Gian G.; Vabulas, R. Martin published an article in 2020, the title of the article was The protective role of m1A during stress-induced granulation.Quality Control of N-Methyl-7H-purin-6-amine And the article contains the following content:
Post-transcriptional methylation of N6-adenine and N1-adenine can affect transcriptome turnover and translation. Furthermore, the regulatory function of N6-methyladenine (m6A) during heat shock has been uncovered, including the enhancement of the phase separation potential of RNAs. In response to acute stress, e.g. heat shock, the orderly sequestration of mRNAs in stress granules (SGs) is considered important to protect transcripts from the irreversible aggregation. Until recently, the role of N1-methyladenine (m1A) on mRNAs during acute stress response remains largely unknown. Here we show that the methyltransferase complex TRMT6/61A, which generates the m1A tag, is involved in transcriptome protection during heat shock. Our bioinformatics anal. indicates that occurrence of the m1A motif is increased in mRNAs known to be enriched in SGs. Accordingly, the m1A-generating methyltransferase TRMT6/61A accumulated in SGs and mass spectrometry confirmed enrichment of m1A in the SG RNAs. The insertion of a single methylation motif in the untranslated region of a reporter RNA leads to more efficient recovery of protein synthesis from that transcript after the return to normal temperature Our results demonstrate far-reaching functional consequences of a minimal RNA modification on N1-adenine during acute proteostasis stress. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Quality Control of N-Methyl-7H-purin-6-amine
The Article related to transcriptome n1 methyladenine protective role granulation, n1-methyladenine, stress granules, stress response, Mammalian Pathological Biochemistry: Other and other aspects.Quality Control of N-Methyl-7H-purin-6-amine
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