Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78581-99-4, name is 5,6-Difluorobenzimidazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 78581-99-4
A solution OF 2, 4, 6-TRICHLOROPYRIMIDIN (4.2 gram), 5,6-difluorobenzimidazole (3.6 gram) and K2CO3 (6.4 gram) in dimethyl sulfoxide (150 ml) was stirred at 40 C for 17 hours. The solution was taken up in water, and extracted three times with ethyl acetate. The ethyl acetate layers were combined, washed with brine, dried over magnesium sulfate, filtered, and the solvents were removed in vacuo. Silica gel chromatography (heptane/ethyl acetate 9/1) provided 1.2 g of the title compound.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 78581-99-4.
Reference:
Patent; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2004/69829; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem