Reference of 6160-65-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6160-65-2 as follows.
At 0C, a solution of 1,1′-thiocarbonyldiimidazole (206 mg, 1.10 mmol) in DCM (3 mL) was added dropwise 4-(3-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester (160 mg, 0.58 mmol) in DCM (2 mL) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was cooled again to 0C and a solution of ammonia in MeOH 7N (2 mL) was added dropwise. The reaction mixture was stirred at room temperature for 16 hours. Water was added and extracted with DCM. Purification by flash chromatography (silica gel, gradient to hexanes to 50% acetone). The desired product was obtained as a white foam (180 mg, 93% yield).
According to the analysis of related databases, 6160-65-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S. A.; CUEVAS CORDOBES, FELIX; ALMANSA ROSALES, CARMEN; GARCIA LOPEZ, MONICA; (299 pag.)TW2016/27300; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem